Mice can carry dangerous diseases that are transferrable to people, such as hantavirus, salmonellosis, and plague.
To keep yourself safe, prevent mice from getting into your home.

The Best Mouse Poison

If you’re wondering how to kill a lot of mice, that of a massive infestation as opposed to just one that snuck into your house, poison is often the most successful way to do this. While you might not like the idea of having to use poison, it’s far more economical than purchasing a large number of electric traps.

Poison will also often work better than setting a bunch of snap-traps, which can be easily set off by pets or small children.

How We Found the Best Mouse Poison


4 Reviewers

28 Products Considered

3 Products Reviewed

3 Top Picks

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NEOGEN Rodenticide 45-Pack Ramik Rat and Mouse Bait Pail


  • Well-rated for success by users
  • Excellent value
  • All-weather, indoor or outdoor bait
  • Designed for mice, rats, and voles
  • Can be spread in all types of locations
  • Tamper-resistant lid


  • Can be enticing to pets


This high-rated mouse poison has an excellent rate of effectiveness. The pellets have an appealing protein lure that can be used indoors and outside.

Our Review

NEOGEN Rodenticide 45-Pack Ramik Rat and Mouse Bait Pail is a versatile mouse poison with the anticoagulant active ingredient diphacinone. These pellets can be placed around a garden, in an attic, in a garage—anywhere mice or rats might find them. Just use extreme caution. These pellets can attract pets, too. Wear gloves when dispensing and keep away from kids or your beloved animals.

With 4.2 pounds of bait in this pail, you will have plenty of poison for mice in or around your home. The fish protein lure smell is enticing to rodents, and these pellets can take out rats and voles, also. As with any poison, you’ll have to use gloves and clean up dead rodents right away. As an overall mouse poison, this comes in at the top of our list for its effectiveness and value.


Runner Up


Farnam Just One Bite II Bait Chunks


  • Outstanding ratings
  • Effective against most resistant mice
  • Nibble edges to encourage chewing
  • Fantastic value for eight pounds
  • Bait chunks are more manageable for users to find again
  • Works quickly


  • Can be appealing to pets
  • Must wear gloves to place bait
  • Requires cleanup of dead rodents


With a next-generation mouse poison active ingredient, this is our favorite for warfarin or diphacinone-resistant mice. The high customer feedback is a testament to the success rate of this product.

Our Review

The Farnam Just One Bite II Bait Chunks are our favorite blocks for mice resistant to warfarin while still using an anticoagulant toxin. With eight pounds of chucks in this container, you will have an ample amount to spread wherever you need them. We love the design of these mice poison chunks, as they have “nibble edges” to encourage mice to chew on them.

These chunks not only work against mice but will also take out large rats and believe it or not, even cockroaches. So, if you have a multiple-pest problem, this an exceptional poison that will work across the board. If you find the chunks seem too big to appeal to mice while wearing gloves and a dust mask, you can break these bait chunks into even smaller pieces and crumble a bit of bread in with the poison.




EcoClear RatX All-Natural Non-Toxic Humane Rat and Mouse Killer Pellets


  • Safe around pets and other types of wildlife
  • Budget-friendly
  • No risk of garden or crop contamination/li>
  • Designed explicitly for mice and rats
  • Available in various sized bags
  • Easy-to-spread and mix pellets
  • Made in the USA


  • According to reviews, some mice are resistant


If you need mouse poison but have multiple pets or an overly hungry or curious dog, this is our pick for a safer mouse poison. It’s designed to only work against the digest system of mice and rats, without harming other wildlife.

Our Review

EcoClear RatX Non-Toxic Humane Rat and Mouse Killer Pellets are crafted to kill mice and rats while keeping other pets and wildlife safe. These pellets work by slowing the digestive and circulatory system of mice, causing them to become lethargic and then go to sleep… forever.

If you’re concerned about a pet getting into mice bait, this is a fantastic option to try out. We like that you can mix other bits of food in with the pellets, and the small design of this poison can be placed in tight corners, holes, or spread over larger spaces. EcoClear can also be used as an excellent lure in conjunction with other methods, such as snap traps and electric mouse traps.

Different Types of Mouse Poison

If you need tried mouse poison before, it’s helpful to know there are a few different types. First-generation mouse poisons are usually anticoagulants that take a few days to work. These include warfarin, but there are also newer versions like diphacinone and brodifacoum.

Some mice and rats are now resistant to certain types of anticoagulants. So, if these don’t work for you, another class might be necessary.

Bromethalin is in its own class altogether. It works as a neurotoxin, targeting both the brain and liver. It’s crucial to know that there is no antidote to bromethalin. So, if you have pets or small children, we recommend steering clear of this mouse poison if possible. Bromethalin can be extremely useful, working within hours rather than days. You need to weigh the risks of having this around your home and yard, however.

After Mice Poisons Work

The half-life of many of these mouse poisons is several days, which is why it’s crucial to dispose of dead rodents immediately when you find them. The bait toxins will remain in the body, and if they’re discovered by other wildlife or your pets, the poison can be transferred.

Wearing gloves and a dust mask, wrap dead mice in a plastic bag before disposing of them in the trash—away from the reach of pets and other animals.


There’s a reason mouse poison is used so widely and by most pest control companies: it works and takes care of a large number of rodents within a relatively short time. You must take the utmost care when disturbing mouse poison and quickly disposing of dead rodents. If you have a large mouse issue and single traps or mouse repellents are not enough, poison is often the best way to go.

Remember, mice can carry some diseases that can harm your pets or your family, even though their waste left behind after the mouse moves away from any given spot. So, if a mouse population is out of control, know that you’re doing what you can to protect your family and pets by ridding rodents from your home.